You have probably read about the devastating quake in Haiti. The FP blog names a number of place you can give to help. Normally I would not chime in, but sometimes I have a personal connection to an NGO that really makes a difference, and people appreciate the pointer to an organization they previously would not have known.
My brother Kent started an organization called Haiti Partners with several Haitian colleagues. It has one of the most fantastic operating cultures I know. They have an Earthquake Response Fund.
If you want to give to a place that you know will be effective (especially because so many funds will be choking the main pipelines) consider that one.
Update: they are working to get a new Earthquake Fund set up, but in the meantime a general contribution will be going to the relief efforts. Also, the tax ID is 232713126.